Abstract
Background: Serological evaluation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an alternative that allows us to determine the prevalence and dynamics of this infection in populations. The goal of this study was to determine the clinical and sociodemographic dynamics of SARS-CoV-2 infection in a region of the Colombian Caribbean.
Methods: Between July and November 2020, a cross-sectional observational study was carried out in Córdoba, located in northeast Colombia in the Caribbean area. Eight municipalities with the largest populations were chosen and 2564 blood samples were taken. A commercial enzyme-linked immunosorbent assay was used with the recombinant protein antigen N of SARS-CoV-2. The people included in the study were asked for sociodemographic and clinical data, which were analysed by statistical methods.
Results: A seroprevalence of 40.8% was obtained for SARS-CoV-2 in the Córdoba region. In the bivariate analysis, no differences were observed in seropositivity against SARS-CoV-2 for gender or age range (p>0.05). Higher seropositivity was found in low socio-economic status and symptomatic patients (p<0.0001). A total of 30.7% of the asymptomatic patients were seropositive for SARS-CoV-2, which could be linked to the spread of this infection. In the multivariate analysis, seroconversion was related to poverty and clinical manifestations such as anosmia and ageusia (p<0.05).
Conclusions: The high seropositivity in Córdoba is due to widespread SARS-CoV-2 in this population. The relationship between seropositivity and socio-economic status suggests a higher exposure risk to the virus caused by informal economic activities in low-income groups. Clinical manifestations such as anosmia and ageusia could be clinical predictors of infection by the new emergent coronavirus.
Keywords: asymptomatic infections; economic conditions; informal social controls; public health; seroepidemiologic studies; social conditions.
【저자키워드】 public health, asymptomatic infections, Seroepidemiologic studies, economic conditions, informal social controls, social conditions., 【초록키워드】 SARS-CoV-2, coronavirus, cross-sectional, SARS-COV-2 infection, Infection, Gender, risk, virus, Population, Anosmia, Antigen, activity, Spread, Prevalence, Protein, Seroconversion, Asymptomatic, Ageusia, age, predictor, seropositive, asymptomatic patient, Analysis, clinical manifestation, acute respiratory syndrome, Clinical data, no difference, blood sample, Sociodemographic, Córdoba, widespread, populations, statistical, enzyme-linked immunosorbent, was used, caused, carried, analysed, determine, groups, conditions, was obtained, asked, symptomatic patient, was related, 【제목키워드】 SARS-CoV-2, Immunity, outcome, Sociodemographic, eight,