Abstract
In the context of the current SARS-CoV-2 pandemic, associations of drugs which interfere with specific steps of the viral infectious cycle are currently being exploited as therapeutic strategies since a specific treatment by vaccination is still unavailable. A widespread association of repurposed agents is the combination of the antimalarial drug Hydroxychloroquine and the macrolide antibiotic Azithromycin in the setting of clinical trials. But a closer analysis of their mechanism of action suggests that their concomitant administration may be impractical, and this is supported by experimental data with other agents of the same classes. However a sequential administration of the lysosomotropic antimalarial with the addition of the macrolide proton pump inhibitor after the first has reached a certain threshold could better exploit their antiviral potential.
Keywords: Antimalarials; COVID-19; Coronavirus; Macrolide antibiotics; SARS-CoV-2; Sequential.
【저자키워드】 COVID-19, SARS-CoV-2, coronavirus, Antimalarials, Macrolide antibiotics, Sequential., 【초록키워드】 vaccination, Azithromycin, Macrolide, Hydroxychloroquine, Antiviral, SARS-CoV-2 pandemic, clinical trials, drug, antimalarial, Viral, Therapeutic strategies, inhibitor, threshold, mechanism of action, therapeutic strategy, association, antibiotic, Combination, administration, Analysis, proton pump, antimalarial drug, specific treatment, widespread, addition, supported, interfere, reached,