Abstract
Recent studies have reported the protective efficacy of both natural 1 and vaccine-induced 2-7 immunity against challenge with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus macaques. However, the importance of humoral and cellular immunity for protection against infection with SARS-CoV-2 remains to be determined. Here we show that the adoptive transfer of purified IgG from convalescent rhesus macaques (Macaca mulatta) protects naive recipient macaques against challenge with SARS-CoV-2 in a dose-dependent fashion. Depletion of CD8 + T cells in convalescent macaques partially abrogated the protective efficacy of natural immunity against rechallenge with SARS-CoV-2, which suggests a role for cellular immunity in the context of waning or subprotective antibody titres. These data demonstrate that relatively low antibody titres are sufficient for protection against SARS-CoV-2 in rhesus macaques, and that cellular immune responses may contribute to protection if antibody responses are suboptimal. We also show that higher antibody titres are required for treatment of SARS-CoV-2 infection in macaques. These findings have implications for the development of SARS-CoV-2 vaccines and immune-based therapeutic agents.
【초록키워드】 Treatment, SARS-CoV-2, IgG, Efficacy, coronavirus, Immunity, Cellular immune response, SARS-COV-2 infection, Antibody Response, CD8, SARS-CoV-2 vaccine, T cell, cellular immunity, therapeutic agents, macaque, convalescent, Protective, Antibody titre, rhesus macaques, macaques, rhesus macaque, natural immunity, humoral, acute respiratory syndrome, antibody titres, transfer, Depletion, implication, recent, PROTECT, reported, required, contribute, dose-dependent, purified, abrogated, infection with SARS-CoV-2, 【제목키워드】 SARS-CoV-2, rhesus macaque,