Abstract
High antibody titers have been found to correlate with the severity of coronavirus disease 2019 (COVID-19) disease. Therefore, antibody titers may be higher in older adults, whose disease is known to have a more severe course than younger ones. This study aimed to compare the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) antibody level in the reverse transcription-polymerase chain reaction (RT-PCR) to test positive older adults with young. Patients aged ≥18 with positive RT-PCR and checked serum IgG antibodies between November 1, 2020 and January 13, 2021 were included. The IgG antibody levels and the time between RT-PCR positivity with the antibody levels were recorded. A total of 1071 patients were divided into two groups as Group 1 <60 years old (n = 902) and Group 2 ≥60 years old (n = 169). The SARS-CoV-2 IgG antibody titers were higher in Group 2 (p = 0.001). This height was present in the first 3 months after positive RT-PCR. While the antibody titers were compared by dividing Group 2 into the three groups according to age ranges (60-69, 70-79, and ≥80 years), the antibody titer was higher in ≥80 years patients (p = 0.044). High COVID-19 IgG antibody levels may be associated with the severity of the disease. Also, the humoral immunity advantage was seen in the first 3 months in the older patients, which suggests that older adults with COVID-19 may develop reinfection in the long term.
Keywords: COVID-19; SARS-CoV-2; antibody; older adults; seroconversion.
【저자키워드】 COVID-19, SARS-CoV-2, Older adults, antibody, Seroconversion, 【초록키워드】 coronavirus disease, IgG, coronavirus, severity, RT-PCR, Adults, Humoral immunity, Reinfection, Seroconversion, IgG antibody, Immunoglobulin, SARS-CoV-2 IgG antibody, Patient, Antibody titer, age, group, disease, positive RT-PCR, older patients, acute respiratory syndrome, Older, positive, while, Course, develop, the disease, two group, checked, three group, were recorded, serum IgG antibody, with COVID-19, 【제목키워드】 Older adults, Seroconversion, Older,