Abstract
The current Coronavirus Disease 2019 (COVID-19) pandemic is causing great alarm around the world. The pathogen for COVID-19 – severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – is the seventh known coronavirus to cause pneumonia in humans. While much remains unknown about SARS-CoV-2, physicians and researchers have begun to publish relevant findings, and much evidence is available on coronaviruses previously circulating in human and animal populations. In this review, we situate COVID-19 in its context as a transboundary viral disease, and provide a comprehensive discussion focused on the discovery, spread, virology, pathogenesis, and clinical features of this disease, its causative coronaviral pathogen, and approaches to combating the disease through immunotherapies and other treatments and vaccine development. An epidemiological survey revealed a potentially large number of asymptomatic SARS-CoV-2 carriers within the population, which may hamper efforts against COVID-19. Finally, we emphasize that vaccines against SARS-CoV-2, which may be developed by 2021, will be essential for prevention of COVID-19.
Keywords: Human coronavirus; origin; pathogenesis; public health; respiratory viruses; sars-CoV-2.
【저자키워드】 public health, SARS-CoV-2, Pathogenesis, origin, respiratory viruses, human coronavirus, 【초록키워드】 COVID-19, coronavirus disease, public health, SARS-CoV-2, Coronavirus disease 2019, Vaccine, Vaccine development, coronavirus, pandemic, Pathogenesis, Virology, Pneumonia, Immunotherapy, Human, severe acute respiratory syndrome Coronavirus, Clinical features, respiratory viruses, Spread, Asymptomatic, pathogen, humans, epidemiological survey, viral disease, respiratory, disease, clinical feature, Evidence, acute respiratory syndrome, acute respiratory syndrome coronavirus, immunotherapies, effort, other treatments, circulating, physician, Coronaviral, carrier, while, researcher, approach, populations, combating, prevention of COVID-19, human coronavirus, the disease, other treatment, 【제목키워드】 coronavirus, Immunotherapy, disease,