Abstract
Background: In liver transplant (LT) recipients with severe coronavirus disease 2019 (COVID-19), fatal outcome has been reported in a substantial subset of patients. Whether LT recipients are at increased risk for severe COVID-19 compared with the general population is controversial. Here we report the results of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serosurvey in a large LT recipient cohort.
Methods: A total of 219 LT recipients were enrolled between May 5, 2020, and August 6, 2020, at the University Hospital Heidelberg. Serum blood samples were collected and tested for anti-SARS-CoV-2 IgG. SARS-CoV-2 RNA was detected in nasopharyngeal swabs using reverse transcription-polymerase chain reaction assays.
Results: Taking into account known risk factors of arterial hypertension, obesity, diabetes, or leukopenia, LT recipients a priori represented a high-risk cohort for severe COVID-19 with 101 of 219 (46.1%) presenting with more than 2 risk factors for severe COVID-19. Out of 219 LT recipients, 8 (3.7%) either had a positive test result for nasopharyngeal SARS-CoV-2 RNA or anti-SARS-CoV-2 serum IgG. Five of eight (62.5%) did not show any clinical signs of infection, three of eight (37.5%) had self-limited disease, and none required hospitalization for COVID-19. Two of eight (25%) had known exposure to infected health care staff as the probable source of infection.
Conclusions: In summary, LT recipients showed a SARS-CoV-2 seroconversion rate similar to that of the general population with a substantial percentage of unrecognized infections.
【초록키워드】 COVID-19, SARS-CoV-2, coronavirus, severe COVID-19, Hospitalization, obesity, Infection, diabetes, outcome, risk factor, anti-SARS-CoV-2, Nasopharyngeal swab, Cohort, Health, infections, Serosurvey, anti-SARS-CoV-2 IgG, nasopharyngeal, SARS-CoV-2 RNA, General population, disease, Care, liver, patients, Arterial hypertension, source of infection, acute respiratory syndrome, increased risk, recipients, severe coronavirus disease, blood sample, leukopenia, serum IgG, seroconversion rate, positive test result, recipient, Clinical sign, enrolled, tested, collected, reported, assays, required, eight, subset, presenting, Taking, University Hospital Heidelberg, 【제목키워드】 COVID-19, SARS-CoV-2, Seroprevalence, Transplant, clinical, Prospective, recipient,