Abstract
Exacerbation of rheumatic disease after vaccination against SARS-CoV-2 is being reported. However, there are only a few cases of new-onset rheumatic diseases. We present two cases of new-onset persistent polyarthritis that developed in patients after receiving the mRNA vaccine against SARS-CoV-2. One patient had bilateral pleural effusions with markedly elevated serum interferon (IFN)-β, while the other had no effusion, with serum IFN-β comparable with that in healthy subjects. Other cytokines were unaltered in association with effusion. Both patients responded well to treatment with 20 mg prednisolone. Although more investigations are needed, the marked increase in serum IFN-β levels observed in the case with pleural effusion may reflect an excessive response from the innate immune system to mRNA vaccines.
Keywords: COVID-19; immunological products and vaccines; immunology; musculoskeletal syndromes.
【저자키워드】 COVID-19, immunology, immunological products and vaccines, musculoskeletal syndromes., 【초록키워드】 Treatment, SARS-CoV-2, Rheumatic diseases, vaccination, mRNA vaccine, interferon, cytokine, mRNA vaccines, innate immune system, serum, Patient, Other, disease, association, Prednisolone, Exacerbation, Musculoskeletal, healthy subjects, IFN-β, one patient, polyarthritis, immunological, reported, elevated, receiving, increase in, comparable, had no, 【제목키워드】 BNT162b2 mRNA, polyarthritis,