Abstract
In the COVID-19 pandemic, drug repositioning has presented itself as an alternative to the time-consuming process of generating new drugs. This review describes a drug repurposing process that is based on a new data-driven approach: we put forward five information paths that associate COVID-19-related genes and COVID-19 symptoms with drugs that directly target these gene products, that target the symptoms or that treat diseases that are symptomatically or genetically similar to COVID-19. The intersection of the five information paths results in a list of 13 drugs that we suggest as potential candidates against COVID-19. In addition, we have found information in published studies and in clinical trials that support the therapeutic potential of the drugs in our final list.
Keywords: COVID-19; Data-driven approaches; Drug repurposing; SARS-COV-2.
【저자키워드】 COVID-19, Drug repurposing, SARS-CoV-2., Data-driven approaches, 【초록키워드】 Drug repurposing, clinical trial, COVID-19 pandemic, drugs, clinical trials, Symptom, drug, information, disease, COVID-19 symptoms, COVID-19 symptom, Support, alternative, therapeutic potential, candidate, Final, treat, list, Intersection, FIVE, data-driven, addition, time-consuming, 【제목키워드】 heterogeneous, facilitate,