Abstract
Background: The recent pandemic by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global emergency. There is large number of asymptomatic cases of SARS-CoV-2 that are not reported. Hence, serological evidence of SARS-CoV2 antibodies is warranted for a better estimation of the actual number of infected patients to limit the disease spread and to get an idea of herd immunity.
Methods: This is a cross-sectional study conducted from May 2020 to July 2020 at National Institute of Blood Diseases at Pakistan. The study includes healthcare workers (HCWs), community and industrial workers. The anti-SARS-CoV-2 test was performed by electrochemiluminescence immunoassay analyzer.
Results: A total of 1675 samples have been received from three groups of population. The percentage positivity for industrial employees is high (50.3%) for HCW (13.2%) and community population (34%).Total percentage for positive antibodies result is ~36%.
Conclusion: Our seroprevalence is 36%, which still far from herd immunity that needs to be at least 60-70% in population. If we consider acquiring 60% seroprevalence in next few months, then herd immunity is not far from reality, provided the antibodies did not decline with time. Although the current study is based on a small sample of participants, the findings suggest a study with larger population to implement stronger and targeted interventions.
Keywords: infectious disease; public health.
【저자키워드】 public health, Infectious disease, 【초록키워드】 public health, SARS-CoV-2, coronavirus, SARS-CoV2, pandemic, Immunity, antibody, cross-sectional, anti-SARS-CoV-2, healthcare worker, Spread, HCWs, Patient, Community, Asymptomatic case, HCW, acute respiratory syndrome, Participants, targeted interventions, positive, electrochemiluminescence immunoassay, serological evidence, limit, include, reported, the disease, conducted, provided, was performed, number of infected, three group, the antibody, 【제목키워드】 Immunity, Seroprevalence, COVID 19, anti-SARS-CoV-2 antibody,