Abstract
We investigated whether the antibody response to coronavirus disease 2019 (COVID-19) mRNA vaccination is similar in women and men. In a community cohort without prior COVID-19, first vaccine dose produced higher immunoglobulin G (IgG) levels and percent inhibition of spike-ACE2 receptor binding, a surrogate measure of virus neutralization, in women compared to men (7.0 µg/mL, 51.6% vs 3.3 µg/mL, 36.4%). After 2 doses, IgG levels remained significantly higher for women (30.4 µg/mL) compared to men (20.6 µg/mL), while percent inhibition was similar (98.4% vs 97.7%). Sex-specific antibody response to mRNA vaccination informs future efforts to understand vaccine protection and side effects.
Keywords: COVID-19; ELISA; IgG; SARS-CoV-2; dried blood spots; neutralizing; receptor binding domain; serological testing; vaccine.
【저자키워드】 COVID-19, SARS-CoV-2, IgG, Vaccine, ELISA, Receptor binding domain, Dried blood spots, Serological testing, Neutralizing, 【초록키워드】 coronavirus disease, mRNA vaccination, Vaccine, Antibody Response, vaccine dose, Cohort, Immunoglobulin, Virus neutralization, Community, women, Side effects, serological, Blood, Receptor binding, effort, doses, men, produced, investigated, remained, significantly higher, the antibody response, IgG level, 【제목키워드】 Immunoglobulin G, mRNA, Level,