Abstract
Objectives: Patients with APS and triple-positive for aPL are at high risk of recurrent events. As COVID-19 and COVID-19 vaccination may induce thrombotic complications, the objective of the study was to assess the course of COVID-19 and adverse events after vaccination in these patients.
Methods: This is a nationwide multicentre survey conducted in nine APS referral centres by means of a questionnaire. Included patients are thrombotic APS with triple-positive aPL confirmed 12 weeks apart. Reference specialist physicians used a four-graded scale of severity for COVID-19 [from 0 (asymptomatic) to 3 (hospitalization in intensive care unit)] and a six-graded scale for adverse reactions to vaccination [from 0 (transient local injection site sign/symptoms) to 5 (potentially life-threatening reactions)]. Outcomes were considered within a 30-day period.
Results: Out of 161 patients interviewed, 18 (11%) had COVID-19. All of them fully recovered without any progression to severe disease nor thromboembolic event. A total of 146 patients received the first (92%) and 129 (80%) the second dose of vaccine; side effects were minimal and, in most cases (83% after the first and 68% after the second vaccination) limited to a sore arm. Fifteen patients (9%) were unvaccinated. Most of them raised doubts on the need for vaccination, complained of poor safety and in general were reluctant about COVID-19 vaccination.
Conclusion: Patients with triple-positive thrombotic APS did not suffer from severe COVID-19 outcomes. Importantly, COVID-19 vaccination was well tolerated. These data may reassure patients and physicians and contribute to reducing hesitancy in unvaccinated patients.
Keywords: APS; COVID-19; thrombosis; vaccination.
【저자키워드】 COVID-19, thrombosis, vaccination., APS, 【초록키워드】 vaccination, intensive care, severe COVID-19, Hospitalization, Thrombotic complications, severity, Local, progression, outcomes, Asymptomatic, COVID-19 vaccination, adverse event, Patient, multicentre, questionnaire, patients, severe disease, Adverse reaction, high risk, Side effect, second vaccination, second dose, thrombotic, injection, physician, MOST, Thromboembolic event, reference, Course, raised, conducted, events, nine, contribute, reducing, induce, potentially life-threatening, 【제목키워드】 COVID-19 vaccination, Impact, high-risk patient,