Abstract
The severity of disease of Covid-19 is highly variable, ranging from asymptomatic to critical respiratory disease and death. Potential cross-reactive immune responses between SARS-CoV-2 and endemic coronavirus (eCoV) may hypothetically contribute to this variability. We herein studied if eCoV nucleoprotein (N)-specific antibodies in the sera of patients with mild or severe Covid-19 are associated with Covid-19 severity. There were comparable levels of eCoV N-specific antibodies early and during the first month of infection in Covid-19 patients with mild and severe symptoms, and healthy SARS-CoV-2-negative subjects. These results warrant further studies to investigate the potential role of eCoV-specific antibodies in immunity to SARS-CoV-2 infection.
Keywords: COVID-19; disease severity; endemic coronaviruses; nucleoprotein-specific antibodies.
【저자키워드】 COVID-19, disease severity, Endemic coronaviruses, nucleoprotein-specific antibodies., 【초록키워드】 antibodies, SARS-CoV-2, coronavirus, Immunity, antibody, SARS-COV-2 infection, severity, Infection, Asymptomatic, sera, Respiratory disease, Patient, death, Mild, Severity of disease, disease, Critical, Endemic, Variability, severe symptoms, healthy, subjects, contribute, comparable, Potential, cross-reactive immune response, 【제목키워드】 coronavirus, antibody, Patient, Mild, Endemic,