Abstract
Objectives: At the present time, there is an absence of any proven effective antiviral therapy for patients with coronavirus disease 2019 (COVID-19). The aim of this study was to assess the efficacy of intravenous immunoglobulin (IVIG) in non-severe patients with COVID-19.
Methods: A retrospective study based on propensity score matching (PSM) was designed. Primary outcomes included the severity and mortality rates. Secondary outcomes included the duration of fever, virus clearance time, length of hospital stay, and use of antibiotics.
Results: A total of 639 non-severe patients with COVID-19 were enrolled. Forty-five patients received IVIG therapy and 594 received non-IVIG therapy. After PSM (1:2 ratio), the baseline characteristics were well balanced between the IVIG group (n = 45) and control group (n = 90). No statistically significant difference was found between the IVIG group and control group in the duration of fever (median 3 vs 3 days, p = 0.667), virus clearance time (median 11 vs 10 days, p = 0.288), length of hospital stay (median 14 vs 13 days, p = 0.469), or use of antibiotics (40% vs 38.9%, p = 0.901). Meanwhile, compared to the IVIG group, no more patients in the control group progressed to severe disease (3.3% vs 6.6%, p = 0.376) or died (0 vs 2.2%, p = 0.156).
Conclusions: In non-severe patients with COVID-19, no benefit was observed with IVIG therapy beyond standard therapy.
Keywords: Coronavirus disease 2019; Efficacy evaluation; Intravenous immunoglobulin; Mortality; Severe acute respiratory syndrome coronavirus 2.
【저자키워드】 severe acute respiratory syndrome coronavirus 2, Coronavirus disease 2019, Intravenous immunoglobulin, Mortality, Efficacy evaluation, 【초록키워드】 COVID-19, coronavirus disease, antiviral therapy, Efficacy, coronavirus, therapy, severity, outcome, Retrospective study, Patient, mortality rates, disease, PSM, propensity score matching, Standard therapy, severe disease, Hospital stay, acute respiratory syndrome, control group, baseline characteristics, virus clearance, statistically significant difference, effective, benefit, secondary, enrolled, died, median, absence, duration of fever, non-severe patient, progressed, use of antibiotics, with COVID-19, 【제목키워드】 propensity score matching, retrospective cohort study, non-severe patient,