Abstract
Patients with transfusion-dependent thalassaemia (TDT) are considered an at increased-risk population for severe and/or morbid coronavirus disease 2019 (COVID-19) infection. Timely vaccination is the main preventive method for severe COVID-19. Different adverse events and reactions after vaccination have been reported, with severe ones being extremely rare. Patients with TDT may have altered immunity due to chronic transfusions, iron overload and chelation therapy, and splenic dysfunction. Here, we show that adult patients with TDT following vaccination with the novel messenger RNA vaccines have mild adverse events and can produce protective antibodies comparable to the healthy population.
Keywords: coronavirus disease 2019 (COVID-19); thalassaemia; vaccines.
【저자키워드】 Vaccines, Coronavirus disease 2019 (COVID-19), thalassaemia, 【초록키워드】 COVID-19, coronavirus disease, Vaccine, vaccination, therapy, severe COVID-19, Immunity, Vaccines, Infection, adverse event, Patient, Mild, Protective antibody, dysfunction, Messenger RNA, reaction, reported, comparable, the healthy, 【제목키워드】 SARS-CoV-2, vaccination, adverse event, Patient,