Abstract
In this study we report on the clinical and autoimmune characteristics of severe and critical novel coronavirus pneumonia caused by severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2). The clinical, autoimmune, and laboratory characteristics of 21 patients who had laboratory-confirmed severe and critical cases of coronavirus disease 2019 (COVID-19) from the intensive care unit of the Huangshi Central Hospital, Hubei Province, China, were investigated. A total of 21 patients (13 men and 8 women), including 8 (38.1%) severe cases and 13 (61.9%) critical cases, were enrolled. Cough (90.5%) and fever (81.0%) were the dominant symptoms, and most patients (76.2%) had at least one coexisting disorder on admission. The most common characteristics on chest computed tomography were ground-glass opacity (100%) and bilateral patchy shadowing (76.2%). The most common findings on laboratory measurement were lymphocytopenia (85.7%) and elevated levels of C-reactive protein (94.7%) and interleukin-6 (89.5%). The prevalence of anti-52 kDa SSA/Ro antibody, anti-60 kDa SSA/Ro antibody, and antinuclear antibody was 20%, 25%, and 50%, respectively. We also retrospectively analyzed the clinical and laboratory data from 21 severe and critical cases of COVID-19. Autoimmune phenomena exist in COVID-19 subjects, and the present results provide the rationale for a strategy of preventing immune dysfunction and optimal immunosuppressive therapy.
【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, coronavirus, therapy, intensive care, Pneumonia, antibody, interleukin-6, C-reactive protein, Symptoms, Novel coronavirus, Laboratory, Prevalence, China, Chest computed tomography, ground-glass opacity, Characteristics, lymphocytopenia, Fever, Patient, laboratory characteristics, Autoimmune, women, Admission, Critical, immune dysfunction, immunosuppressive, critical cases, Critical case, laboratory data, Severe case, disorder, laboratory-confirmed, dominant, men, enrolled, analyzed, caused, investigated, elevated, subjects, kDa, patchy, 【제목키워드】 COVID-19, clinical,