Abstract
We aim to study kinetics of anti-SARS-CoV-2 IgG antibody levels in subjects with COVID-19 for up to 11 months and the potential influential factors. The study was a prospective longitudinal study. The analyses were based on 77 serum/plasma samples with a mean of 4 samples per participant (range 1 – 18) in 20 participants with at least one positive Polymerase Chain Reaction testing result from 19 March 2020 up to 10 February 2021. Among the subjects (median age 34.5 years, 65% male), IgG level declined with the follow-up time (per month; geometric mean ratio [GMR] 0.73; 95% CI, 0.72 – 0.74). In a small sample of subjects from the general population with COVID-19, IgG levels declined non-linearly from month 2 to 11 with individual heterogeneity in quantity and changing speed and may be associated with gender, race and the loss of smell and taste.
Keywords: COVID-19; IgG; SARS-CoV-2; antibody; coronavirus; kinetics.
【저자키워드】 COVID-19, SARS-CoV-2, IgG, coronavirus, antibody, Kinetics, 【초록키워드】 Gender, heterogeneity, anti-SARS-CoV-2 IgG, male, Factors, General population, Analysis, Loss of Smell, 95% CI, reaction, subject, geometric mean ratio, median age, chain, serum/plasma, participant, follow-up time, positive, declined, IgG level, with COVID-19, 【제목키워드】 Kinetics, anti-SARS-CoV-2 IgG, follow-up study, Factor, subject,