Abstract
The risk of a hemolytic reaction during the transfusion of ABO non-identical PC is determined by the presence of natural anti-A IgM antibodies, the titer of which may increase after infections. The aim of the study was to evaluate the titer of anti-A isohemagglutinins in platelet concentrate (PC) obtained by apheresis from group O donors who experienced SARS-CoV-2 infection, and to compare the titer before and after infection. A retrospective single-center analysis of 21 PC donors with a previous COVID-19 history was performed. The results showed neither a statistically important increase in the anti-A IgM antibody titers nor a significant correlation between the anti-A IgM antibody level and anti-SARS-CoV-2S1 antibody titer in the donors with an asymptomatic or mild COVID-19. Further population-based studies on anti-A titers are necessary for a comprehensive assessment of this phenomenon.
Keywords: COVID-19; SARS-CoV-2; isohemagglutinin; platelet; transfusion.
【저자키워드】 COVID-19, SARS-CoV-2, Platelet, transfusion, isohemagglutinin, 【초록키워드】 SARS-COV-2 infection, Infection, risk, infections, Asymptomatic, IgM antibodies, Antibody titer, Mild, correlation, Donor, retrospective, Analysis, ABO, IgM antibody, single-center, evaluate, was performed, increase in, statistically, 【제목키워드】 Donor, Analysis, retrospective cohort, increase in,