Abstract
In this observational study, 13 patients with severe COVID-19 and 10 healthy controls were enrolled. The data concerning the analysis of circulating T cells show that, in severe COVID-19 patients, the expansion of these cell compartments is prone to induce antibody response, inflammation (CCR4+ and CCR6+ TFH) and regulation (CD8+ Treg). This pathogenic mechanism could lead us to envision a possible new form of biological target therapy.
Keywords: COVID-19; SARS-CoV-2; T lymphocytes; adaptive immunity.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, T lymphocytes, adaptive immunity., 【초록키워드】 Inflammation, therapy, adaptive, severe COVID-19, Immunity, Antibody Response, T cell, Patient, mechanism, Treg, Analysis, Regulation, healthy control, severe COVID-19 patients, pathogenic, circulating, CD8+, Cell, enrolled, induce, concerning, 【제목키워드】 characterization, T lymphocyte, severe COVID-19 patient,
【저자키워드】 COVID-19, SARS-CoV-2, T lymphocytes, adaptive immunity., 【초록키워드】 Inflammation, therapy, adaptive, severe COVID-19, Immunity, Antibody Response, T cell, Patient, mechanism, Treg, Analysis, Regulation, healthy control, severe COVID-19 patients, pathogenic, circulating, CD8+, Cell, enrolled, induce, concerning, 【제목키워드】 characterization, T lymphocyte, severe COVID-19 patient,
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이 관찰 연구에는 중증 COVID-19 환자 13명과 건강한 대조군 10명이 등록되었습니다. 순환하는 T 세포 분석에 관한 데이터는 중증 COVID-19 환자에서 이러한 세포 구획의 확장이 항체 반응, 염증(CCR4+ 및 CCR6+ TFH) 및 조절(CD8+ Treg)을 유도하는 경향이 있음을 보여줍니다. 이 병원성 메커니즘은 생물학적 표적 치료의 가능한 새로운 형태를 상상하도록 이끌 수 있습니다.
{{ 키워드: }} 코로나19; 사스 코로나바이러스 2; T 림프구; 적응 면역.