Abstract
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS coronavirus 2 (SARS-CoV-2) has caused significant morbidity and mortality for patients and stressed healthcare systems worldwide. The clinical features, disease course, and serologic response of COVID-19 among immunosuppressed patients such as solid organ transplant (SOT) recipients, who are at presumed risk for more severe disease, are not well characterized. We describe our institutional experience with COVID-19 among 10 SOT patients, including the clinical presentation, treatment modalities, and outcomes of 7 renal transplant recipients, 1 liver transplant recipient, 1 heart transplant recipient, and 1 lung transplant recipient. In addition, we report the serologic response in SOT recipients, documenting a positive IgG response in all 7 hospitalized patients. We also review the existing literature on COVID-19 in SOT recipients to consolidate the current knowledge on COVID-19 in the SOT population for the transplant community.
Keywords: antibody biology; clinical research/practice; infection and infectious agents – viral; infectious disease.
【저자키워드】 Infectious disease, clinical research/practice, infection and infectious agents - viral, antibody biology, 【초록키워드】 COVID-19, Treatment, coronavirus disease, SARS-CoV-2, pandemic, antibody, knowledge, Infection, risk, Infectious disease, outcome, hospitalized patients, Clinical features, Patient, Community, morbidity and mortality, SARS Coronavirus, liver, lung transplant, Serologic response, solid organ transplant, severe disease, Healthcare system, SOT, IgG response, infectious agent, recipients, disease course, renal, positive, recipient, caused, addition, characterized, immunosuppressed patient, SOT patients, with COVID-19, 【제목키워드】 outcome, clinical, Serologic response, solid organ transplant, recipient, the United State, case sery,