Abstract
As the global COVID-19 pandemic progresses, it is paramount to gain knowledge on adaptive immunity to SARS-CoV-2 in children to define immune correlates of protection upon immunization or infection. We analyzed anti-SARS-CoV-2 antibodies and their neutralizing activity (PRNT) in 66 COVID-19-infected children at 7 (±2) days after symptom onset. Individuals with specific humoral responses presented faster virus clearance and lower viral load associated with a reduced in vitro infectivity. We demonstrated that the frequencies of SARS-CoV-2-specific CD4 + CD40L + T cells and Spike-specific B cells were associated with the anti-SARS-CoV-2 antibodies and the magnitude of neutralizing activity. The plasma proteome confirmed the association between cellular and humoral SARS-CoV-2 immunity, and PRNT + patients show higher viral signal transduction molecules (SLAMF1, CD244, CLEC4G). This work sheds lights on cellular and humoral anti-SARS-CoV-2 responses in children, which may drive future vaccination trial endpoints and quarantine measures policies.
Keywords: Ab-mediated neutralization activity; COVID-19; SARS-CoV-2; anti-SARS-CoV-2 antibodies; antigen-specific B cells; antigen-specific CD4 T cells; pediatric COVID-19; proteomic profiling.
【저자키워드】 COVID-19, SARS-CoV-2, anti-SARS-CoV-2 antibodies, Antigen-specific B cells, Ab-mediated neutralization activity, antigen-specific CD4 T cells, pediatric COVID-19, proteomic profiling., 【초록키워드】 vaccination, adaptive, Immunity, quarantine, neutralization, knowledge, pediatric, children, COVID-19 pandemic, Infection, CD40L, in vitro, CD4, anti-SARS-CoV-2, immunization, SARS-CoV-2 immunity, B cell, Neutralizing activity, T cell, Humoral response, anti-SARS-CoV-2 antibody, Viral load, Patient, plasma, proteome, proteomic, PRNT, association, cellular, Frequency, humoral, symptom onset, virus clearance, individual, measure, CD244, CLEC4G, analyzed, reduced, faster, demonstrated, magnitude, to define, humoral anti-SARS-CoV-2 response, immune correlate, SLAMF1, trial endpoint, viral signal, 【제목키워드】 neutralizing antibody, children, immunological, feature, develop,