SARS-CoV-2 spike antigen-specific IgG and IgA elicited by infection mediate viral neutralization and are likely an important component of natural immunity, however, limited information exists on vaccine induced responses. We measured COVID-19 mRNA vaccine induced IgG and IgA in serum serially, up to 145 days post vaccination in 4 subjects. Spike antigen-specific IgG levels rose exponentially and plateaued 21 days after the initial vaccine dose. After the second vaccine dose IgG levels increased further, reaching a maximum approximately 7–10 days later, and remained elevated (average of 58% peak levels) during the additional >100 day follow up period. COVID-19 mRNA vaccination elicited spike antigen-specific IgA with similar kinetics of induction and time to peak levels, but more rapid decline in serum levels following both the 1 st and 2 nd vaccine doses (<18% peak levels within 100 days of the 2 nd shot). The data demonstrate COVID-19 mRNA vaccines effectively induce spike antigen specific IgG and IgA and highlight marked differences in their persistence in serum.
【초록키워드】 COVID-19, IgG, mRNA vaccination, Vaccine, spike, mRNA vaccine, Infection, mRNA vaccines, Antigen, vaccine dose, serum, Viral, IgA, persistence, viral neutralization, information, SARS-CoV-2 spike, natural immunity, COVID-19 mRNA vaccine, peak levels, COVID-19 mRNA Vaccination, COVID-19 mRNA vaccines, Serum level, SARS-CoV-2 spike antigen, serum levels, spike antigen-specific IgA, average, post vaccination, responses, highlight, initial, remained, elevated, subjects, induce, elicited, IgG level, 【제목키워드】 IgG, Human, COVID-19 mRNA vaccine, IgA response,