Abstract
Interleukin-6 (IL-6) is a multi-tasking cytokine that represents high activity in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and cancer. High concentration of this pleiotropic cytokine accounts for hyperinflammation and cytokine storm, and is related to multi-organ failure in patients with SARS-CoV-2 induced disease. IL-6 promotes lymphopenia and increases C-reactive protein (CRP) in such cases. However, blockade of IL-6 is not a full-proof of complete response. Hypoxia, hypoxemia, aberrant angiogenesis and chronic inflammation are inter-related events occurring as a response to the SARS-CoV-2 stimulatory effect on high IL-6 activity. Taking both pro- and anti-inflammatory activities will make complex targeting IL-6 in patient with SARS-CoV-2 induced disease. The aim of this review was to discuss about interactions occurring within the body of patients with SARS-CoV-2 induced disease who are representing high IL-6 levels, and to determine whether IL-6 inhibition therapy is effective for such patients or not. We also address the interactions and targeted therapies in cancer patients who also have SARS-CoV-2 induced disease.
Keywords: C-reactive protein (CRP); Cancer; Cytokine storm; Hypoxia; Inflammation; Interleukin-6 (IL-6); Pneumonia; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Tocilizumab.
【저자키워드】 Inflammation, Cytokine storm, hypoxia, Tocilizumab, Pneumonia, Cancer, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Interleukin-6 (IL-6), C-reactive protein (CRP), 【초록키워드】 SARS-CoV-2, coronavirus, therapy, IL-6, C-reactive protein, Angiogenesis, cytokine, anti-inflammatory activity, lymphopenia, hyperinflammation, Hypoxemia, Patient, chronic inflammation, targeted therapy, disease, IL-6 inhibition, Interaction, Concentration, IL-6 levels, cancer patient, C-reactive protein (CRP, acute respiratory syndrome, complex, multi-organ failure, blockade, Complete, effective, event, increase, determine, promote, representing, stimulatory, pleiotropic, Taking, patient with SARS-CoV-2, patients with SARS-CoV-2, the SARS-CoV-2, 【제목키워드】 SARS-CoV-2, therapeutic,