Abstract
A 77-year-old man (case R) with previous diagnosis of a mild COVID-19 episode was hospitalized 35 days later. On day 23 postadmission, he developed a second COVID-19 episode, now severe, and finally died. Initially, case R’s COVID-19 recurrence was interpreted as a reinfection due to the exposure to a SARS-CoV-2 RT-PCR-positive roommate. However, whole-genome sequencing indicated that case R’s recurrence corresponded to a reactivation of the strain involved in his first episode. Case R’s reactivation had major consequences, leading to a more severe episode, and causing subsequent transmission to another 2 hospitalized patients, 1 of them with fatal outcome.
Keywords: COVID-19; SARS-CoV-2; WGS; nosocomial transmission; reactivation.
【저자키워드】 COVID-19, SARS-CoV-2, Reactivation, Nosocomial transmission, WGS, 【초록키워드】 whole-genome sequencing, Hospitalized, nosocomial, Diagnosis, Transmission, outcome, hospitalized patients, Consequences, Reinfection, Mild, died, involved, indicated, subsequent, Initially, 【제목키워드】 Reactivation, recurrence, Initially,