Abstract
Secondary cold agglutinin syndrome (CAS) is autoimmune hemolytic anemia secondary to infections and lymphoid disorder. We here report the first Asian case of CAS secondary to novel coronavirus disease 2019 (COVID-19). A 72-year-old Japanese woman presented with a 2-week history of dyspnea and cough, and laboratory data revealed severe hemolytic anemia with a hemoglobin level of 4.7 g/dL. She was diagnosed with COVID-19, CAS, and monoclonal gammopathy of undetermined significance (MGUS). The anemia responded to corticosteroids administered for COVID-19 and required maintenance therapy. Although corticosteroids are not a standard therapy for CAS, they might be effective for CAS secondary to COVID-19 complicated with MGUS.
Keywords: COVID-19; autoimmune hemolytic anemia; cold agglutinin syndrome; corticosteroid; monoclonal gammopathy of undetermined significance.
【저자키워드】 Corticosteroid, COVID-19, autoimmune hemolytic anemia, cold agglutinin syndrome, monoclonal gammopathy of undetermined significance., 【초록키워드】 Anemia, therapy, Infection, novel coronavirus disease, cough, Dyspnea, Autoimmune, hemoglobin, Japanese, monoclonal, Standard therapy, CAS, hemolytic anemia, Asian, laboratory data, syndrome, disorder, lymphoid, Undetermined, Administered, effective, secondary, required, diagnosed with COVID-19, 【제목키워드】 IgM, Cold, gammopathy, Agglutinin, Significance,