Abstract
In this observational study, 159 patients with multiple sclerosis received personalized dosing of ocrelizumab incentivized by the COVID-19 pandemic. Re-dosing was scheduled when CD19 B-cell count was ⩾10 cells/µL (starting 24 weeks after the previous dose, repeated 4-weekly). Median interval until re-dosing or last B-cell count was 34 [30-38] weeks. No clinical relapses were reported and a minority of patients showed Expanded Disability Status Scale (EDSS) progression. Monthly serum neurofilament light levels remained stable during extended intervals. Two (1.9%) of 107 patients with a follow-up magnetic resonance imaging (MRI) scan showed radiological disease activity. Personalized dosing of ocrelizumab could significantly extend intervals with low short-term disease activity incidence, encouraging future research on long-term safety and efficacy.
Keywords: COVID-19; Multiple sclerosis; neurofilament light; ocrelizumab; personalized dosing.
【저자키워드】 COVID-19, multiple sclerosis, Neurofilament light, Ocrelizumab, personalized dosing., 【초록키워드】 Efficacy, magnetic resonance imaging, COVID-19 pandemic, progression, MRI, serum, Research, Patient, disability, Follow-up, scale, incidence, B-cell, Disease activity, dose, CD19, status, Multiple, EDSS, intervals, repeated, radiological, significantly, reported, remained, interval, 【제목키워드】 COVID-19 pandemic, Patient, B-cell,