Abstract
Adaptive immune responses to SARS-CoV-2 infection have been extensively characterized in blood; however, most functions of protective immunity must be accomplished in tissues. Here, we report from examination of SARS-CoV-2 seropositive organ donors (ages 10 to 74) that CD4 + T, CD8 + T, and B cell memory generated in response to infection is present in the bone marrow, spleen, lung, and multiple lymph nodes (LNs) for up to 6 months after infection. Lungs and lung-associated LNs were the most prevalent sites for SARS-CoV-2–specific memory T and B cells with significant correlations between circulating and tissue-resident memory T and B cells in all sites. We further identified SARS-CoV-2–specific germinal centers in the lung-associated LNs up to 6 months after infection. SARS-CoV-2–specific follicular helper T cells were also abundant in lung-associated LNs and lungs. Together, the results indicate local tissue coordination of cellular and humoral immune memory against SARS-CoV-2 for site-specific protection against future infectious challenges.
【초록키워드】 SARS-CoV-2, immune response, SARS-COV-2 infection, Infection, lung, Local, CD4, CD8, Bone marrow, B cell, protective immunity, B cell memory, Lungs, Germinal center, immune memory, correlation, seropositive, function, spleen, Donor, cellular, Lymph node, humoral, tissue, tissues, circulating, organ, memory T, prevalent, helper T cell, characterized, follicular, LNs, 【제목키워드】 SARS-COV-2 infection, Human, Immunological memory, generate,