Abstract
Background: Studies presenting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) for healthy individuals are warranted. We estimate IFR by age and comorbidity status using data from a large serosurvey among Danish blood donors and nationwide data on coronavirus disease 2019 (COVID-19) mortality.
Methods: Danish blood donors aged 17-69 years donating blood October 2020-February 2021 were tested with a commercial SARS-CoV-2 total antibody assay. IFR was estimated for weeks 11 to 42, 2020 and week 43, 2020 to week 6, 2021, representing the first 2 waves of COVID-19 epidemic in Denmark.
Results: In total, 84944 blood donors were tested for antibodies. The seroprevalence was 2% in October 2020 and 7% in February 2021. Among 3898039 Danish residents aged 17-69 years, 249 deaths were recorded. The IFR was low for people <51 years without comorbidity during the 2 waves (combined IFR=3.36 per 100000 infections). The IFR was below 3‰ for people aged 61-69 years without comorbidity. IFR increased with age and comorbidity but declined from the first to second wave.
Conclusions: In this nationwide study, the IFR was very low among people <51 years without comorbidity.
Keywords: SARS-CoV-2; blood donors; infection fatality rate; seroprevalence.
【저자키워드】 SARS-CoV-2, Seroprevalence, Blood donors, Infection fatality rate, 【초록키워드】 COVID-19, coronavirus disease, antibodies, coronavirus, Mortality, antibody, Infection, Comorbidity, infections, Serosurvey, death, second wave, age, Denmark, Blood, fatality, COVID-19 epidemic, IFR, blood donor, acute respiratory syndrome, Fatality rate, tested, representing, presenting, healthy individual, declined, were recorded, 【제목키워드】 COVID-19, Screening, Blood donors, Denmark, estimation, status, Rate,