Abstract
Background: Exposure, risks and immunity of healthcare workers (HCWs), a vital resource during the SARS-CoV-2 pandemic, warrant special attention.
Methods: HCWs at Helsinki University Hospital, Finland, filled in questionnaires and provided serum samples for SARS-CoV-2-specific antibody screening by Euroimmun IgG assay in March-April 2020. Positive/equivocal findings were confirmed by Abbott and microneutralization tests. Positivity by two of the three assays or RT-PCR indicated a Covid-19 case (CoV+).
Results: The rate of CoV(+) was 3.3% (36/1095) and seropositivity 3.0% (33/1095). CoV(+) was associated with contact with a known Covid-19 case, and working on a Covid-19-dedicated ward or one with cases among staff. The rate in the Covid-19-dedicated ICU was negligible. Smoking and age <55 years were associated with decreased risk. CoV(+) was strongly associated with ageusia, anosmia, myalgia, fatigue, fever, and chest pressure. Seropositivity was recorded for 89.3% of those with prior documented RT-PCR-positivity and 2.4% of those RT-PCR-negative. The rate of previously unidentified cases was 0.7% (8/1067) and asymptomatic ones 0% (0/36).
Conclusion: Undiagnosed and asymptomatic cases among HCWs proved rare. An increased risk was associated with Covid-19-dedicated wards. Particularly high rates were seen for wards with liberal HCW-HCW contacts, highlighting the importance of social distancing also among HCWs.
Keywords: Antibody response; Covid-19; HCW; Healthcare staff; Neutralizing antibodies; SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, Healthcare staff, Neutralizing antibodies, Antibody Response, HCW, 【초록키워드】 SARS-CoV-2, IgG, pandemic, Immunity, fatigue, social distancing, risk, RT-PCR, healthcare worker, ICU, Anosmia, Asymptomatic, Ageusia, HCWs, Chest, Fever, Asymptomatic case, Seropositivity, age, antibody screening, university, resource, questionnaire, microneutralization, exposure, Contact, myalgia, Abbott, increased risk, serum sample, Helsinki, indicated, provided, highlighting, liberal, the SARS-CoV-2, was recorded, 【제목키워드】 SARS-COV-2 infection, Symptom, risk factor, healthcare worker, university, Helsinki,