Abstract
The subclinical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection rate in hospitals during the pandemic remains unclear. To evaluate the effectiveness of our hospital’s current nosocomial infection control measures, we conducted a serological survey of anti-SARS-CoV-2 antibodies (immunoglobulin [Ig] G) among the staff of our hospital, which is treating coronavirus disease 2019 (COVID-19) patients.The study design was cross-sectional. We measured anti-SARS-CoV-2 IgG in the participants using a laboratory-based quantitative test (Abbott immunoassay), which has a sensitivity and specificity of 100% and 99.6%, respectively. To investigate the factors associated with seropositivity, we also obtained some information from the participants with an anonymous questionnaire. We invited 1133 staff members in our hospital, and 925 (82%) participated. The mean age of the participants was 40.0 ± 11.8 years, and most were women (80.0%). According to job title, there were 149 medical doctors or dentists (16.0%), 489 nurses (52.9%), 140 medical technologists (14.2%), 49 healthcare providers (5.3%), and 98 administrative staff (10.5%). The overall prevalence of seropositivity for anti-SARS-CoV-2 IgG was 0.43% (4/925), which was similar to the control seroprevalence of 0.54% (16/2970) in the general population in Osaka during the same period according to a government survey conducted with the same assay. Seropositive rates did not significantly differ according to job title, exposure to suspected or confirmed COVID-19 patients, or any other investigated factors.The subclinical SARS-CoV-2 infection rate in our hospital was not higher than that in the general population under our nosocomial infection control measures.
【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, coronavirus, pandemic, cross-sectional, SARS-COV-2 infection, hospital, Prevalence, immunoassay, Measures, Immunoglobulin, anti-SARS-CoV-2 antibody, Sensitivity and specificity, anti-SARS-CoV-2 IgG, Effectiveness, Nosocomial infection, Study design, age, General population, infection rate, women, quantitative test, information, questionnaire, COVID-19 patients, Nurse, Abbott, Government, dentist, acute respiratory syndrome, Factor, Healthcare provider, participant, serological survey, Medical doctor, evaluate, significantly, investigated, conducted, participated, 【제목키워드】 cross-sectional, hospital, Seroprevalence, SARS-CoV-2 antibody, COVID-19 patient,