Abstract
We investigated the duration of humoral and T-cell immune response in paired samples among 22 convalescent healthcare workers (HCWs). A median of 1.8 months after diagnosis, T-cell response was significantly lower in HCWs with early loss of antibodies (6 cases [27%]). After 5.1 months, antibody decline was observed in 77% of cases (41% seroreverted; P < .01), and 36% had lost T-cell response (75% lost response to spike protein). Persistence of immune response was observed in those who developed a greater adaptive immune response. Our data point to the initial immune response as the relevant player in coronavirus disease 2019 duration of protection.
Keywords: SARS-CoV-2; adaptive immune response; convalescent; duration; healthcare workers; immune response.
【저자키워드】 SARS-CoV-2, immune response, Healthcare workers, Duration, Adaptive immune response, convalescent, 【초록키워드】 coronavirus disease, immune response, adaptive, antibody, T-cell Response, Diagnosis, healthcare worker, immune, Spike protein, HCWs, healthcare, T-cell, humoral, HCW, significantly lower, initial, greater, investigated, median, 【제목키워드】 coronavirus 2, respiratory, Decline, worker, Progressive,