Abstract
Introduction: COVID-19 infections have become an urgent worldwide public health concern. Although it is primarily a respiratory disease, up to two-thirds of hospitalised COVID-19 patients exhibit nervous system damage and an increased risk of frailty. In this study,we aim to investigate the relationship between frailty and cognitive function disorders in patients with COVID-19 with a systematic review and meta-analysis approach.
Methods and analysis: This meta-analysis has been registered by the International Prospective Register of Systematic Reviews. We will search for relevant studies from PubMed, Embase, Chinese Biological Medical Database, China National Knowledge Infrastructure, Wanfang Database, the Cochrane Central Register of Controlled Trials databases, from their inception to 5 July 2021. We will also search reference lists of selected articles for additional studies. Our search strategy will have no language restrictions. We will employ a fixed or random-effects model to calculate OR and 95% CIs for pooled data, and assess heterogeneity using Cochrane’s Q and I 2 tests. The primary outcome will be the rate of cognitive disorders related to frailty in old patients with COVID-19.
Ethics and dissemination: Ethical approval is not essential since data will be extracted from previously published studies. The results of this meta-analysis will be published in a peer-reviewed journal.
Prospero registration number: CRD42021257148.
Keywords: COVID-19; delirium & cognitive disorders; geriatric medicine; mental health; old age psychiatry.
【저자키워드】 COVID-19, mental health, delirium &, cognitive disorders, geriatric medicine, old age psychiatry., 【초록키워드】 Meta-analysis, public health, mental health, Ethics, frailty, systematic review, heterogeneity, psychiatry, cognitive disorders, geriatric medicine, China, COVID-19 infection, delirium, Prospective, Respiratory disease, nervous system, Cognitive function, age, respiratory, Biological, systematic reviews, registration number, old age, cognitive, Infrastructure, Primary outcome, PROSPERO, 95% CI, increased risk, hospitalised COVID-19 patients, COVID-19 infections, Chinese, Registered, random-effects model, Ethical approval, 95% CIs, article, disorder, Mental, approach, selected, Controlled, peer-reviewed, calculate, hospitalised COVID-19 patient, patients with COVID-19, 【제목키워드】 Meta-analysis, protocol, Patient, Cognitive function, disorder,