Abstract
The pathogenesis of autoimmune complications triggered by SARS-CoV2 has not been completely elucidated. Here, we performed an analysis of the cellular immune status, cell ratios, and monocyte populations of patients with COVID-19 treated in the intensive care unit (ICU) (cohort 1, N = 23) and normal care unit (NCU) (cohort 2, n = 10) compared with control groups: patients treated in ICU for noninfectious reasons (cohort 3, n = 30) and patients treated in NCU for infections other than COVID-19 (cohort 4, n = 21). Patients in cohort 1 presented significant differences in comparison with the other cohorts, including reduced frequencies of lymphocytes, reduced CD8+T-cell count, reduced percentage of activated and intermediate monocytes and an increased B/T8 cell ratio. Over time, patients in cohort 1 who died presented with lower counts of B, T, CD4 + T, CD8 + T-lymphocytes, NK cells, and activated monocytes. The B/T8 ratio was significantly lower in the group of survivors. In cohort 1, significantly higher levels of IgG1 and IgG3 were found, whereas cohort 3 presented higher levels of IgG3 compared to controls. Among many immune changes, an elevated B/T8-cell ratio and a reduced rate of activated monocytes were mainly observed in patients with severe COVID-19. Both parameters were associated with death in cohort 1.
Keywords: Autoimmunity ⋅ B/T-cell ratio ⋅ COVID-19 ⋅ Lymphocytes ⋅ Monocytes.
【저자키워드】 Autoimmunity ⋅ B/T-cell ratio ⋅ COVID-19 ⋅ Lymphocytes ⋅ Monocytes., 【초록키워드】 COVID-19, Monocytes, SARS-CoV2, Pathogenesis, Lymphocytes, intensive care, severe COVID-19, Infection, NK cells, CD4, CD8, ICU, Population, monocyte, Cohort, Survivors, T-lymphocytes, Patient, death, Complication, Autoimmune, IgG3, Care, IgG1, Immune status, cellular, Frequency, Analysis, significant difference, cohorts, immune changes, significantly lower, parameter, over, controls, Cell, performed, died, elevated, reduced, treated, activated, significantly higher, triggered, patients treated, patients with COVID-19, 【제목키워드】 monocyte, B-cell, activated, Increased, severe COVID-19 patient,