Abstract
Background: Reversible splenial lesion syndrome (RESLES) is characterized by a temporary lesion in the splenium of the corpus callosum, emerging related to encephalitis, seizures, antiepileptic drug withdrawal, or metabolic disturbances. Among RESLES, mild encephalitis/encephalopathy with reversible splenial lesion (MERS) has been defined as a distinct clinicoradiologic syndrome associated with viral infections.
Case presentation: We report two children with multisystem inflammatory syndrome-children related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who developed RESLES during the disease course. Encephalopathy was the main central nervous system symptom. Both of the children showed a rapid recovery, and brain magnetic resonance imaging revealed complete resolution of the splenial lesion within 1 week.
Conclusion: The complete resolution of the splenial lesion and rapid recovery from encephalopathy in RESLES associated with SARS CoV-2 were similar to observed in MERS.
Keywords: Child; Coronavirus; Corpus callosum; Encephalitis.
【저자키워드】 coronavirus, Child, Corpus callosum, Encephalitis., 【초록키워드】 SARS CoV-2, SARS-CoV-2, magnetic resonance imaging, children, Symptom, Withdrawal, MERS, viral infections, Brain, Encephalitis, Mild, Encephalopathy, Central nervous system, Inflammatory, Seizures, acute respiratory syndrome, syndrome, metabolic disturbances, corpus, Complete, Course, defined, the disease, characterized, callosum, Reversible, splenial, 【제목키워드】 SARS-COV-2 infection, children, syndrome, Reversible, splenial,