Abstract
The presence of memory T cells in COVID-19 patients has been acknowledged, however the functional potency of memory responses is critical for protection. In this study, naïve, effector, effector memory, and central memory CD4 + and CD8 + T cells obtained from the COVID-19 survivors were re-exposed to autologous monocyte-derived DCs that were loaded with SARS-CoV-2 spike glycoprotein S1. Proliferation capacity, CD25, 4-1BB, and PD-1 expression, and IFN-γ, IL-6, granzyme, granulysin, and FasL secretion were enhanced in CD4 + and CD8 + effector memory and central memory T cells. Albeit being at heterogeneous levels, the memory T cells from the individuals with COVID-19 history possess functional capacities to reinvigorate anti-viral immunity against SARS-CoV-2.
Keywords: Central memory T cells, Effector memory T cells, Spike S1 glycoprotein; Cytotoxic T lymphocytes; Dendritic cell; Helper T cells; SARS-CoV-2.
【저자키워드】 SARS-CoV-2., dendritic cell, cytotoxic T lymphocytes, helper T cells, Central memory T cells, Effector memory T cells, Spike S1 glycoprotein, 【초록키워드】 COVID-19, SARS-CoV-2, spike, T cells, IL-6, CD4, CD8, T cell, SARS-CoV-2 spike glycoprotein, memory T cells, expression, Critical, CD25, memory T cell, IFN-γ, memory response, COVID-19 patient, secretion, naïve, heterogeneous, effector, survivor, cytotoxic, effector memory, helper, Anti-viral immunity, autologous, functional, central memory, individuals with COVID-19, monocyte-derived DC, 【제목키워드】 memory T cell, COVID-19 patient,