Abstract
Immune thrombocytopenia (ITP) is an autoimmune condition characterized by platelet destruction through antibody-mediated mechanism. ITP is one of the manifestations of a coronavirus disease, as well as an adverse event occurring after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several cases of ITP have been described after vaccination with two mRNA-based vaccines-BTN162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna)-against SARS-CoV-2. Herein, we report a case of ITP occurring after vaccination with ChAdOx1 adenovirus vector nCoV-19 (AstraZeneca) vaccine in Korea. A 66-year-old woman presented with multiple ecchymoses on both upper and lower extremities and gingival bleeding, appearing 3 days after receiving the first dose of ChAdOx1 nCoV-19. Her laboratory results showed isolated severe thrombocytopenia without evidence of combined coagulopathy. She was diagnosed with ITP and successfully treated with high-dose dexamethasone and intravenous immunoglobulin. Clinical suspicion to identify vaccine-related ITP is important to promptly initiate appropriate treatment.
Keywords: COVID-19; ChAdOx1 nCoV-19; Immune Thrombocytopenia; SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, ChAdOx1 nCoV-19, Immune thrombocytopenia, 【초록키워드】 Dexamethasone, Treatment, coronavirus disease, SARS-CoV-2, Intravenous immunoglobulin, Vaccine, coronavirus, vaccination, mRNA-1273, Coagulopathy, Adenovirus, clinical, adverse event, Platelet, Autoimmune, ChAdOx1, Pfizer-BioNTech, mechanism, AstraZeneca, Evidence, manifestation, High-dose, acute respiratory syndrome, first dose, described, identify, diagnosed, receiving, characterized, treated, gingival bleeding, laboratory result, mRNA-based, 【제목키워드】 thrombocytopenia, ChAdOx1 nCoV-19, Immune thrombocytopenia, report,