Abstract
The COVID-19 pandemic is still raging across the world and vaccination is expected to lead us out of this pandemic. Although the efficacy of the vaccines is beyond doubt, safety still remains a concern. We report a case of a 65-year-old woman who experienced acute severe autoimmune hepatitis two weeks after receiving the first dose of Moderna-COVID-19 vaccine. Serum immunoglobulin G was elevated and antinuclear antibody was positive (1:100, speckled pattern). Liver histology showed a marked expansion of the portal tracts, severe interface hepatitis and multiple confluent foci of lobular necrosis. She started treatment with prednisolone, with a favorable clinical and analytical evolution. Some recent reports have been suggested that COVID-19 vaccination can lead to the development of autoimmune diseases. It is speculated that the vaccine can disturb self-tolerance and trigger autoimmune responses through cross-reactivity with host cells. Therefore, healthcare providers must remain vigilant during mass COVID-19 vaccination.
Keywords: Autoimmune hepatitis; COVID-19 vaccine; Moderna mRNA vaccine.
【저자키워드】 COVID-19 vaccine, Autoimmune hepatitis, Moderna mRNA vaccine., 【초록키워드】 COVID-19, Treatment, Evolution, Necrosis, Efficacy, Vaccine, vaccination, pandemic, antibody, COVID-19 pandemic, cross-reactivity, COVID-19 vaccination, Immunoglobulin, Hepatitis, Autoimmune diseases, Autoimmune response, Prednisolone, host cells, Healthcare provider, first dose, positive, foci, Liver histology, self-tolerance, Moderna mRNA vaccine, elevated, receiving, suggested, the vaccine, expected, lobular, 【제목키워드】 Hepatitis,