Abstract
The development of autoimmune diseases has been reported after SARS-CoV-2 infection. Vaccination against SARS-CoV-2 could also trigger auto-immunity, as it has been described with other vaccines. An aberrant immune response induced by molecular mimicry and bystander activation, especially in predisposed individuals, is a potential mechanism. We report the case of a 76-year-old woman with Hashimoto thyroiditis and prior COVID-19 infection who developed severe autoimmune hepatitis (with typical features including strongly positive anti-smooth muscle antibody and markedly elevated immunoglobulins G, as well as typical histological findings) following SARS-CoV-2 vaccination (mRNA-1273 SARS-CoV-2 vaccine, Moderna®). The link between SARS-CoV-2 vaccination and the development of autoimmune diseases needs to be further investigated. Although a causality relationship cannot be proven, caution may be warranted when vaccinating individuals with known autoimmune diseases.
Keywords: Autoimmune hepatitis; COVID-19; SARS-CoV-2; Vaccination.
【저자키워드】 COVID-19, SARS-CoV-2, vaccination, Autoimmune hepatitis, 【초록키워드】 Vaccines, antibody, mRNA-1273, SARS-COV-2 infection, SARS-CoV-2 vaccine, Autoimmune disease, Immunoglobulin, COVID-19 infection, molecular, Autoimmune diseases, SARS-CoV-2 vaccination, bystander, Activation, potential mechanism, individual, positive, aberrant immune response, Hashimoto thyroiditis, feature, described, reported, investigated, elevated, individuals, histological, 【제목키워드】 Hepatitis, SARS-CoV-2 vaccination, triggered,