Abstract
Sample panels of SARS-CoV-2 cases were retrospectively whole-genome sequenced. In three individuals, samples of upper and lower respiratory tract resulted in identical sequences suggesting virus stability including the spike protein cleavage site. In a fourth case, low-level intra-host genomic evolution and a unique 5-nucleotide deletion was observed.
Keywords: Intra-host virus evolution; ORF8 5-nucleotide deletion; Postmortem; S-614D; SARS-CoV-2 genome sequences; Upper and lower respiratory tract.
All Keywords
【저자키워드】 Postmortem, Intra-host virus evolution, ORF8 5-nucleotide deletion, S-614D, SARS-CoV-2 genome sequences, Upper and lower respiratory tract., 【초록키워드】 Evolution, SARS-CoV-2, virus, stability, ORF8, SARS-CoV-2 genome, genomic, Lower respiratory tract, sequence, cleavage site, upper, whole-genome, Sample, sequenced, unique, the spike protein, individuals, 【제목키워드】 SARS-CoV-2, Genetic, virus, Analysis, Lower respiratory tract, COVID-19 patient, tissue specific,
【저자키워드】 Postmortem, Intra-host virus evolution, ORF8 5-nucleotide deletion, S-614D, SARS-CoV-2 genome sequences, Upper and lower respiratory tract., 【초록키워드】 Evolution, SARS-CoV-2, virus, stability, ORF8, SARS-CoV-2 genome, genomic, Lower respiratory tract, sequence, cleavage site, upper, whole-genome, Sample, sequenced, unique, the spike protein, individuals, 【제목키워드】 SARS-CoV-2, Genetic, virus, Analysis, Lower respiratory tract, COVID-19 patient, tissue specific,
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SARS-CoV-2 사례의 샘플 패널은 소급적으로 전체 게놈 시퀀싱되었습니다. 3명의 개인에서 상부 및 하부 호흡기 샘플은 스파이크 단백질 절단 부위를 포함하여 바이러스 안정성을 시사하는 동일한 서열을 생성했습니다. 네 번째 경우에는 낮은 수준의 숙주 내 게놈 진화와 독특한 5-뉴클레오티드 결실이 관찰되었습니다.
{{ 키워드: }} 숙주 내 바이러스 진화; ORF8 5-뉴클레오티드 결실; 검시; S-614D; SARS-CoV-2 게놈 서열; 상부 및 하부 호흡기.