Abstract
Direct myocardial and vascular injuries due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-driven inflammation is the leading cause of acute cardiac injury associated with coronavirus disease 2019 (COVID-19). However, in-depth knowledge of the injury characteristics of the heart affected by inflammation is lacking. In this study, using a quantitative spatial proteomics strategy that combines comparative anatomy, laser-capture microdissection, and histological examination, we establish a region-resolved proteome map of the myocardia and microvessels with obvious inflammatory cells from hearts of patients with COVID-19. A series of molecular dysfunctions of myocardia and microvessels is observed in different cardiac regions. The myocardia and microvessels of the left atrial are the most susceptible to virus infection and inflammatory storm, suggesting more attention should be paid to the lesion and treatment of these two parts. These results can guide in improving clinical treatments for cardiovascular diseases associated with COVID-19.
Keywords: COVID-19; CP: Cell biology; CP: Molecular biology; SARS-CoV-2; heart; inflammation; myocardial and microvessel injury; proteomics.
【저자키워드】 COVID-19, SARS-CoV-2, Inflammation, heart, proteomics., CP: Molecular biology, CP: Cell biology, myocardial and microvessel injury, 【초록키워드】 Treatment, coronavirus disease, proteomics, coronavirus, knowledge, cardiovascular disease, Acute cardiac injury, Characteristics, proteome, virus infection, molecular, Quantitative, Injury, Clinical treatment, inflammatory cell, dysfunction, Vascular injury, acute respiratory syndrome, inflammatory storm, Anatomy, Direct, regions, susceptible, Myocardial, affected, histological, myocardia, patients with COVID-19, with COVID-19, 【제목키워드】 proteome, mechanism, Heart injury, reveal,