Abstract
While severe coronavirus 2019 (COVID-19) is associated with immune activation at the maternal-fetal interface, responses to asymptomatic/mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy remain unknown. Here, we assess immunological adaptations in blood and term decidua in response to asymptomatic/mild disease in pregnant women. We report attenuated antigen presentation and type I interferon (IFN) signaling pathways, loss of tissue-resident decidual macrophages, and upregulated cytokine/chemokine signaling in monocyte-derived decidual macrophages. Furthermore, we describe increased frequencies of activated tissue-resident T cells and decreased abundance of regulatory T cells with infection while frequencies of cytotoxic CD4/CD8 T cells are increased in the blood. In contrast to decidual macrophages, type I IFN signaling is higher in decidual T cells. Finally, infection leads to a narrowing of T cell receptor diversity in both blood and decidua. Collectively, these observations indicate that asymptomatic/mild COVID-19 during pregnancy results in remodeling of the immunological landscape of the maternal-fetal interface, with a potential for long-term adverse outcomes for the offspring.
Keywords: COVID-19; CP: Immunology; CP: Microbiology; SARS-CoV-2; T cells; TCR; decidua; macrophages; placenta; pregnancy.
【저자키워드】 COVID-19, SARS-CoV-2, macrophages, Placenta, T cells, TCR, decidua, CP: Immunology, CP: Microbiology, pregnancy., 【초록키워드】 coronavirus, Infection, type I interferon, adverse outcome, pregnant women, T cell, Pregnancy, Regulatory T cell, immune activation, response, IFN, Antigen presentation, Coronavirus 2019, T cell receptor, disease, signaling pathways, Blood, Signaling, Frequency, Type I IFN, observation, acute respiratory syndrome, CD4/CD8, offspring, while, immunological, activated, upregulated, 【제목키워드】 SARS-COV-2 infection, RNA sequencing, immunological, reveal,