Abstract
Coronavirus disease 2019 (COVID-19) severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2 infection) can lead to intensive care unit (ICU) admission and critical illness myopathy (CIM). We examined 3 ICU patients with COVID-19 who required mechanical ventilation for pneumonia and developed CIM. Pathological examination of the skeletal muscle biopsies revealed myopathic changes consistent with CIM, variable inflammation with autophagic vacuoles, SARS-CoV immunostaining + fibers/granules, and electron microscopy findings of mitochondrial abnormalities and coronavirus-like particles. Although mitochondrial dysfunction with compromised energy production is a critical pathogenic mechanism of non-COVID-19-associated CIM, in our series of COVID-19-associated CIM, myopathic changes including prominent mitochondrial damage suggest a similar mechanism and association with direct SARS-CoV-2 muscle infection. ANN NEUROL 2022;91:568-574.
【초록키워드】 COVID-19, SARS-CoV-2, Inflammation, Coronavirus disease 2019, intensive care, mechanical ventilation, Pneumonia, SARS-CoV, SARS-COV-2 infection, Infection, ICU, Microscopy, mitochondrial dysfunction, change, Admission, Critical, mechanism, association, immunostaining, ANN, biopsy, mitochondrial, Skeletal muscle, Particles, pathogenic, abnormality, myopathic, ICU patient, pathological, examined, required, autophagic, with COVID-19, 【제목키워드】 Myopathy, illness, Effect, Direct,