Abstract
Neurological symptoms are increasingly recognized in SARS-CoV-2 infected individuals. However, the neuropathogenesis remains unclear and it is not possible to define a specific damage pattern due to brain virus infection. In the present study, 33 cases of brain autopsies performed during the first (February-April 2020) and the second/third (November 2020-April 2021) pandemic waves are described. In all the cases, SARS-CoV-2 RNA was searched. Pathological findings are described and compared with those presently published.
Keywords: COVID-19; astrogliosis; bacterial superinfection; chronic inflammation; endovascular microthrombi; hypoxic-ischemic injury; microglia activation; neuropathology.
All Keywords
【저자키워드】 COVID-19, bacterial superinfection, Neuropathology, chronic inflammation, microglia activation, astrogliosis, endovascular microthrombi, hypoxic-ischemic injury, 【초록키워드】 pandemic, Autopsy, Brain, SARS-CoV-2 RNA, virus infection, microglia, Bacterial, SARS-CoV-2 infected individuals, Neurological symptom, pathological, described, performed, searched, to define, increasingly, 【제목키워드】 experience, Italian,
【저자키워드】 COVID-19, bacterial superinfection, Neuropathology, chronic inflammation, microglia activation, astrogliosis, endovascular microthrombi, hypoxic-ischemic injury, 【초록키워드】 pandemic, Autopsy, Brain, SARS-CoV-2 RNA, virus infection, microglia, Bacterial, SARS-CoV-2 infected individuals, Neurological symptom, pathological, described, performed, searched, to define, increasingly, 【제목키워드】 experience, Italian,
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신경학적 증상은 SARS-CoV-2 감염자에게서 점점 더 많이 인식되고 있습니다. 그러나 신경 병인 발생은 불분명하고 뇌 바이러스 감염으로 인한 특정 손상 패턴을 정의하는 것이 불가능합니다. 본 연구에서는 1차(2020년 2월-4월) 및 2차/3차(2020년 11월-2021년 4월) 대유행 기간 동안 수행된 33건의 뇌 부검 사례를 설명합니다. 모든 경우에 SARS-CoV-2 RNA가 검색되었습니다. 병리학적 소견을 설명하고 현재 출판된 것과 비교합니다.
{{ 키워드: }} 코로나19; 성상교세포증; 세균 중복 감염; 만성 염증; 혈관내 미세혈전; 저산소-허혈성 손상; 미세아교세포 활성화; 신경병리학.