Abstract
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. This virus affects the respiratory tract and usually leads to pneumonia in most patients and acute respiratory distress syndrome (ARDS) in 15% of cases. ARDS is one of the leading causes of death in patients with COVID-19 and is mainly triggered by elevated levels of pro-inflammatory cytokines, referred to as cytokine storm. Interleukins, such as interleukin-6 (1L-6), interleukin-1 (IL-1), interleukin-17 (IL-17), and tumor necrosis factor-alpha (TNF-α) play a very significant role in lung damage in ARDS patients through the impairments of the respiratory epithelium. Cytokine storm is defined as acute overproduction and uncontrolled release of pro-inflammatory markers, both locally and systemically. The eradication of COVID-19 is currently practically impossible, and there is no specific treatment for critically ill patients with COVID-19; however, suppressing the inflammatory response may be a possible strategy. In light of this, we review the efficacy of specific inhibitors of IL6, IL1, IL-17, and TNF-α for treating COVID-19-related infections to manage COVID-19 and improve the survival rate for patients suffering from severe conditions.
Keywords: ARDS; COVID-19; CRS; IL-17; IL1; IL6; TNF-α.
【저자키워드】 COVID-19, ARDS, IL6, TNF-α., CRS, IL-17, IL1, 【초록키워드】 SARS-CoV-2, Coronavirus disease 2019, Efficacy, Cytokine storm, Interleukins, Pneumonia, Infection, interleukin-6, virus, Health, Patient, death, pro-inflammatory cytokines, respiratory tract, survival rate, IL-1, TNF-α, acute respiratory distress, Coronavirus-2, Inflammatory response, lung damage, specific inhibitor, Critically ill patient, acute respiratory syndrome, tumor necrosis factor-alpha, syndrome, specific treatment, impairment, respiratory epithelium, pro-inflammatory, Affect, IMPROVE, defined, caused, elevated, cause, triggered, conditions, systemically, ARDS patient, patients with COVID-19, 【제목키워드】 Cytokine storm, Intervention,