Abstract
At global level, the pandemic coronavirus disease 2019 (COVID-19) is known to be caused by an etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Numerous evidence and propositions have emerged on the molecular and cellular attributes that cause COVID-19. Notwithstanding, still several key questions with reference to molecular aspects of severity of infection by SARS-CoV-2 need to be answered. In the same line, the role of healthy mitochondria to maintain intracellular temperature and their association with the severity of SARS-CoV-2 is completely missing. In this direction, preclinical and clinical data on the comorbidities in the case of mitochondrial defective disease and COVID-19 are not available. The authors propose that patients harboring primary mitochondrial disease and secondary mitochondrial dysfunction will display a higher severity and death rate compared to healthy mitochondria harboring patients.
Keywords: ACE-2; COVID-19; Intracellular temperature; Mitochondria; SPIKE protein.
【저자키워드】 COVID-19, Mitochondria, spike protein., ACE-2, Intracellular temperature, 【초록키워드】 SARS-CoV-2, coronavirus, severity, Comorbidity, Protein, Patient, temperature, molecular, mitochondrial dysfunction, disease, patients, association, cellular, Evidence, pandemic coronavirus, mitochondrial, death rate, Mitochondrial Disease, acute respiratory syndrome, Clinical data, Severity of infection, Intracellular, attribute, caused, healthy, question, maintain, Numerous, 【제목키워드】 Mitochondria, severity, fatality, aggravate,