Abstract
Animal models are at the forefront of biomedical research for studies of viral transmission, vaccines, and pathogenesis, yet the need for an ideal large animal model for COVID-19 remains. We used a meta-analysis to evaluate published data relevant to this need. Our literature survey contained 22 studies with data relevant to the incidence of common COVID-19 symptoms in rhesus macaques ( Macaca mulatta ), cynomolgus macaques ( Macaca fascicularis ), African green monkeys ( Chlorocebus aethiops ), and ferrets ( Mustela putorius furo ). Rhesus macaques had leukocytosis on Day 1 after inoculation and pneumonia on Days 7 and 14 after inoculation, in frequencies that were similar enough to humans to reject the null hypothesis of a Fisher exact test. However, the differences in overall presentation of disease were too different from that of humans to successfully identify any of these 4 species as an ideal large animal of COVID-19. The greatest limitation to the current study is a lack of standardization in experimentation and reporting. To expand our understanding of the pathology of COVID-19 and evalu- ate vaccine immunogenicity, we must extend the unprecedented collaboration that has arisen in the study of COVID-19 to include standardization of animal-based research in an effort to find the optimal animal model.
【초록키워드】 COVID-19, Meta-analysis, pathology, Pathogenesis, Vaccines, Pneumonia, Human, animal model, ferret, animal, Research, Viral transmission, incidence, African green monkey, disease, rhesus macaque, Leukocytosis, Frequency, cynomolgus macaque, Biomedical research, Standardization, vaccine immunogenicity, COVID-19 symptom, null hypothesis, effort, Fisher exact test, identify, lack, evaluate, include, Day, expand, Chlorocebus, 【제목키워드】 COVID-19, ferret, animal, Model, macaque, African green monkey, Chlorocebus,