Abstract
SARS-CoV-2 is a new virus, to which herd immunity has not yet developed and both molecular and serological testing are not without flaws. The virus evokes a state of severe and widespread inflammation, and stimulates both innate and adaptive immune response. The angiotensin-converting enzyme 2 (ACE2), which acts as the SARS-CoV-2 receptor, is present in endothelial cells and has been noted within the human placenta. There are questions about whether pregnancy would increase the susceptibility of pregnant women to COVID-19 and disease severity within this population. In this report, we highlight physiological and immune/inflammatory considerations that may explain the susceptibility and disease pathology in response to SARS CoV-2 during pregnancy, explore testing considerations in asymptomatic individuals, discuss the potential role and of placental ACE2 receptor in the pathogenesis of COVID-19 in pregnancy and in pregnancy outcomes, and finally share our perspective with respect to an urgently needed change concerning involvement of pregnant women in research addressing COVID-19.
Keywords: ACE-2; COVID-19; Immune response; Inflammation; Pregnancy.
【저자키워드】 COVID-19, Inflammation, immune response, ACE-2, Pregnancy, 【초록키워드】 SARS CoV-2, SARS-CoV-2, ACE2, Immunity, Placenta, susceptibility, disease severity, ACE2 receptor, virus, angiotensin-converting enzyme 2, pregnant women, outcomes, Pregnancy, Asymptomatic individuals, Serological testing, Research, placental, receptor, molecular, Adaptive immune response, Endothelial cell, physiological, Perspective, pathogenesis of COVID-19, new virus, disease pathology, widespread, highlight, question, stimulate, explain, concerning, the SARS-CoV-2, would increase, 【제목키워드】 Research, placental, COVID-19 susceptibility,