Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding into the extracellular environment as particle populations contained within vesicles. As a result, this significantly enhances the infectivity of these viruses. In this paper, this novel cellular exit pathway is highlighted and its advantages for viral transmission discussed.
All Keywords
【저자키워드】 Quasispecies, rhinovirus, Viral transmission, RNA virus, enterovirus, coxsackievirus, Poliovirus, picornavirus, secretory autophagy, syntaxin 17,
【저자키워드】 Quasispecies, rhinovirus, Viral transmission, RNA virus, enterovirus, coxsackievirus, Poliovirus, picornavirus, secretory autophagy, syntaxin 17,