Abstract
COVID-19 is increasingly understood as a systemic disease with pathogenic manifestations beyond the respiratory tract. Recent work by Ramani et al (2020) dissects the cellular and molecular mechanisms of SARS-CoV-2’s neurotrophic properties, using viral exposure of human brain organoids. Their findings highlight neurons as primary target of cerebral SARS-CoV-2 infection and uncover its Tau-related neurotoxicity.
All Keywords
【초록키워드】 COVID-19, SARS-CoV-2, SARS-COV-2 infection, respiratory tract, disease, mechanism, brain organoids, manifestation, Neuron, pathogenic, recent, highlight, cellular and molecular, dissect, increasingly, 【제목키워드】 COVID-19, CNS, manifestation, brain organoid,
【초록키워드】 COVID-19, SARS-CoV-2, SARS-COV-2 infection, respiratory tract, disease, mechanism, brain organoids, manifestation, Neuron, pathogenic, recent, highlight, cellular and molecular, dissect, increasingly, 【제목키워드】 COVID-19, CNS, manifestation, brain organoid,
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COVID-19는 호흡기를 넘어 병원성을 나타내는 전신 질환으로 점점 더 이해되고 있습니다. Ramani et al(2020)의 최근 연구는 인간 뇌 오르가노이드의 바이러스 노출을 사용하여 SARS-CoV-2의 신경영양 특성의 세포 및 분자 메커니즘을 분석합니다. 그들의 발견은 뉴런을 대뇌 SARS-CoV-2 감염의 주요 표적으로 강조하고 타우 관련 신경 독성을 밝혀냅니다.