Abstract
Vitamin D regulates homeostasis, anti-microbial response, and inflammation. The vitamin D receptors are expressed in the macrophages and other immune cells, regulating the transcription of many different genes, including those coding the anti-microbial peptides. One of the most severe complications of the SARS-CoV-2 infection is the acute respiratory distress syndrome (ARDS) caused by the hyperinflammatory response (commonly called cytokine storm) of the lung macrophages. Studies showed that Vitamin D deficiency increases the severity of the ARDS in COVID-19 infection. We discuss here how the vitamin D supplementation may influence macrophage and myeloid-derived suppressor cells (MDSCs) inflammatory response, subdue the hyperinflammatory response, and lessen the ARDS in COVID-19 patients.
Keywords: COVID-19; Hyperinflammatory response; Macrophages; Myeloid-derived suppressor cells (MDSCs); SARS-CoV-2; Vitamin D; Vitamin D receptor.
【저자키워드】 COVID-19, SARS-CoV-2, macrophages, Vitamin D, Hyperinflammatory response, Myeloid-derived suppressor cells (MDSCs), Vitamin D receptor., 【초록키워드】 Inflammation, Macrophage, ARDS, Cytokine storm, severity, Transcription, Infection, lung, vitamin D deficiency, COVID-19 infection, Vitamin D receptor, immune cells, Vitamin, receptor, homeostasis, COVID-19 patients, acute respiratory distress, Inflammatory response, regulate, Vitamin D supplementation, coding, syndrome, Hyperinflammatory, Genes, Cell, caused, increase, expressed, severe complication, anti-microbial peptides, anti-microbial response, the SARS-CoV-2, 【제목키워드】 Macrophage, macrophages, Vitamin D, lung, COVID-19 patient, Effect, Hyperinflammatory, Cell,