Abstract
In December 2019, the 2019, a novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) first emerged in Wuhan, China. This has now spread worldwide and was declared a pandemic by March 2020. Initially, the pediatric population was described as a low risk for severe COVID-19. However, reports have emerged recently of cases of COVID-19 in children with a systemic inflammatory disease, with features that overlap with Kawasaki disease (KD). We describe the first 15 cases with the multi-systeminflammatory syndrome in children (MIS-C), temporally related to COVID-19, who presented for care to a tertiary pediatric referral center in New York City. We discuss the disproportionate burden of disease among Hispanic/Latino and Black/African American ancestry, the distinct cytokine signature across the disease spectrum (IL-1/IL-6), and the potential role and pathogenesis of SARS-CoV-2 in this new clinical entity.
Keywords: COVID-19; Kawasaki disease; SARS-CoV-2; hyperinflammatory syndrome.
【저자키워드】 COVID-19, SARS-CoV-2, Hyperinflammatory syndrome, Kawasaki disease, 【초록키워드】 pandemic, severe COVID-19, pediatric, children, risk, cytokine, novel coronavirus disease, New York City, MIS-C, Spread, Hyperinflammatory syndrome, disease, Care, Coronavirus-2, acute respiratory syndrome, overlap, syndrome, pathogenesis of SARS-CoV-2, feature, Wuhan, China, systemic inflammatory, described, caused, the disease, Initially, 【제목키워드】 children, New York City, Inflammatory, syndrome,